ASCOT in Nature Comms

The ASCOT study appeared in Nature Communications today. ASCOT is a new resource allowing researchers to visualize and query alternative splicing patterns in public RNA-Seq data. The resource is freely available at ascot.cs.jhu.edu. To populate ASCOT, we used Snaptron to identify splice-variants across tens of thousands of bulk and single cell RNA-Seq datasets in human…

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Published:January 9, 2020 View Post

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Vargas preprint

Ph.D. student Charlotte Darby and former Masters student Ravi Gaddipati posted a preprint describing their work on Vargas, a heuristic-free read alignment software tool that runs efficiently on modern SIMD and multithreaded architectures. Heuristics are rules that allow aligners to ignore certain portions of the search space that seem to contain only low-scoring alignments. Avoiding…

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Published:December 21, 2019 View Post

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Dashing in Genome Biology

The Dashing study, “Dashing: fast and accurate genomic distances with HyperLogLog,” authored by Daniel Baker appeared in Genome Biology today. Dashing is a fast and accurate software tool for estimating similarities of genomes or sequencing datasets. It uses the HyperLogLog sketch together with cardinality estimation methods that specialize in set unions and intersections. Dashing sketches…

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Published:December 4, 2019 View Post

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Kraken 2 in Genome Biology

Our paper describing the Kraken 2 software tool for metagenomic read classification appeared in Genome Biology. Kraken 2’s memory usage is several-fold smaller than Kraken 1’s. It is also about 5-fold faster and adds a translated search mode for better sensitivity when classifying viruses.  Like Kraken, Kraken 2 works well with the Bracken tool for…

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Published:November 29, 2019 View Post

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Kraken 2 preprint

Derrick Wood, Jennifer Lu and Ben Langmead posted a preprint describing the Kraken 2 software tool, written by Derrick.  Compared to the popular metagenomics read classification tool, Kraken 1, Kraken 2’s memory usage is several-fold smaller, allowing more reference genomes to be used at once. Kraken 2 is about 5-fold faster than Kraken 1, and adds…

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Published:September 8, 2019 View Post

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Joint meeting at NIH

The Langmead lab convoyed down to Bethesda for a daylong joint meeting with the labs of Mike Schatz and Adam Phillippy. Adam hosted us in the beautiful “stone house” on the NIH campus. Some photos are below. It was an excellent day of scientific presentations from trainees in all three labs. Thank you for hosting…

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Published:August 2, 2019 View Post

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Jacob receives doctorate

Congratulations to the lab’s first PhD graduate, Jacob Pritt! He received his doctoral hood in a ceremony at Shriver Hall on Tuesday, May 21, 2019. Best of luck to Jacob who started a position as Junior Bio-Computational Scientist at Mimetics, a company specializing in analysis of dynamic biological networks. Photo courtesy of Nae-Chyun Chen.

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Published:May 23, 2019 View Post

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Samovar wins best paper

Congratulations to PhD student Charlotte Darby for winning the RECOMB-seq 2019 Best Paper award for her paper “Samovar: Single-sample mosaic SNV calling with linked reads.” The preprint is available at: https://www.biorxiv.org/content/10.1101/560532v1, and the full paper is in press at iScience. Many thanks to the organizers for this honor! Samovar is a new software tool for…

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Published:May 6, 2019 View Post

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Bioinformatics & open data review

PI Langmead co-authored a review describing how Bioinformatics training, with the assistance of cloud computing and open data in particular, can enhance STEM research in limited-resource countries and Universities. It appeared in Nature Biotechnology today. The review was primarily the work of Serghei Mangul and Lana Martin at UCLA. A trend highlighted here is the…

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Published:March 5, 2019 View Post

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Samovar preprint

Congratulations to student Charlotte Darby for posting the Samovar preprint! Samovar is a new software tool for detecting mosaic single-nucleotide variants (SNVs) in linked-read whole-genome shotgun sequencing data. It calls mosaic SNVs within a single sample with accuracy comparable to what previously required trios or matched tumor/normal pairs and outperform single-sample mosaic variant callers. The…

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Published:March 1, 2019 View Post

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